Brehler R, Abrams E, Sedlmayr S
Department of Dermatology, University of Münster, Germany.
Allergy. 1998 Apr;53(4):402-6. doi: 10.1111/j.1398-9995.1998.tb03912.x.
The importance of hypersensitivity to Ficus allergens is reported. Cross-sensitization between fig (Ficus carica), weeping fig (F. benjamina [Fb]), and natural rubber latex (NRL) was confirmed by RAST inhibition. We performed skin prick tests with fresh Fb tree sap and NRL extracts in 346 consecutive patients and in 151 patients with immediate-type hypersensitivity to NRL. Total serum IgE and IgE antibodies to NRL and Ficus spp. were analyzed in sera. By the RAST-inhibition method, we studied cross-reactivity among latex, fig, and weeping fig. Sensitization to Fb was diagnosed in 23 of the 346 consecutive patients, and the simultaneous presence of latex-specific IgE was highly significant. Of 151 NRL-allergic patients, 35 were also sensitized to Fb. Cross-reacting IgE antibodies recognizing latex and Ficus allergens were demonstrated by RAST inhibition. The present study reinforces the importance of Fb as an indoor allergen. Cross-reacting IgE antibodies to NRL and Ficus spp. allergens are frequently found in the sera of atopic patients. Development of commercially available standardized extracts for skin tests is urgently necessary.
据报道，对榕树过敏原过敏的重要性。通过放射性变应原吸附试验（RAST）抑制证实了无花果（Ficus carica）、垂叶榕（F. benjamina [Fb]）和天然橡胶乳胶（NRL）之间的交叉致敏。我们对346例连续患者以及151例对NRL有速发型过敏反应的患者进行了新鲜Fb树液和NRL提取物的皮肤点刺试验。对血清中的总血清IgE以及针对NRL和榕属植物的IgE抗体进行了分析。通过RAST抑制法，我们研究了乳胶、无花果和垂叶榕之间的交叉反应性。在346例连续患者中，有23例被诊断为对Fb致敏，同时存在乳胶特异性IgE的情况非常显著。在151例NRL过敏患者中，有35例也对Fb致敏。通过RAST抑制证实了存在识别乳胶和榕属过敏原的交叉反应性IgE抗体。本研究强化了Fb作为室内过敏原的重要性。在特应性患者血清中经常发现针对NRL和榕属植物过敏原的交叉反应性IgE抗体。迫切需要开发用于皮肤试验的市售标准化提取物。
