Rudack C, Sachse F, Jörg S
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Münster.
HNO. 2003 Sep;51(9):694-703. doi: 10.1007/s00106-003-0917-8.
Allergic rhinitis is a very common disease with an increasing prevalence to 10-20% over the last 40 years. These studies propose different reasons for this increase.
An increasing exposure to outdoor allergens is shown in different geographical and climatic areas, like the rising frequency of reactions to cockroaches in Europe or to mites in tropical areas. New aero-allergens have appeared in the animal and vegetable realms, both in home and professional environments. Respiratory allergy to Ficus benjamina inaugurated a new type of allergy caused by airborne allergens from non-pollinating plants. This is specially important because of the cross-reactions to latex.
The immunochemical structures of airborne allergens are now better known, and the homologous structures of different allergens largely explain certain cross-reactions. In the future, recombinant allergens will probably lead to better understanding of the role of allergens in inducing and maintaining the allergic reaction and should promote our approach to diagnosis and therapy.
变应性鼻炎是一种非常常见的疾病,在过去40年中患病率不断上升,达到10% - 20%。这些研究对这种上升提出了不同的原因。
在不同的地理和气候区域,人们接触室外变应原的情况有所增加,比如在欧洲对蟑螂的反应频率上升,在热带地区对螨虫的反应频率上升。在家庭和职业环境中,动植物领域都出现了新的气传变应原。对垂叶榕的呼吸道过敏引发了一种由非授粉植物的气传变应原引起的新型过敏。由于与乳胶的交叉反应,这一点尤为重要。
现在对气传变应原的免疫化学结构有了更好的了解,不同变应原的同源结构在很大程度上解释了某些交叉反应。未来,重组变应原可能会使我们更好地理解变应原在诱导和维持过敏反应中的作用,并应推动我们的诊断和治疗方法。