Sasaki K, Suzuki K, Ueno M, Takako K, Yoshizaki F
Department of Pharmacognosy, Tohoku College of Pharmacy, Sendai, Japan.
Methods Find Exp Clin Pharmacol. 1998 Jan-Feb;20(1):27-30. doi: 10.1358/mf.1998.20.1.485628.
The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the stress-induced increase of monoamines in brain regions was investigated in three mouse emotional stress models. Dopamine (DA) and 3,4-dihydroxy-phenyl acetic acid (DOPAC) contents were elevated significantly by electric shock stress, psychological stress and conditioned fear stress in thalamus, hypothalamus and amygdala. The DA and DOPAC levels were decreased by preadministration of SRBT (600 mg/kg, p.o.) in the last two models, but were not altered in electric shock stress. Therefore, this compound seems to be effective in stress involving emotional factors. These results indicate that SRBT affects the brain monoamine neurons leading to psychological change in mice.
在三种小鼠情绪应激模型中研究了柴胡加龙骨牡蛎汤（SRBT）对脑区应激诱导的单胺增加的影响。电击应激、心理应激和条件性恐惧应激可使丘脑、下丘脑和杏仁核中的多巴胺（DA）和3,4-二羟基苯乙酸（DOPAC）含量显著升高。在前两种模型中，预先给予SRBT（600mg/kg，口服）可降低DA和DOPAC水平，但在电击应激模型中无变化。因此，该化合物似乎对涉及情绪因素的应激有效。这些结果表明，SRBT影响脑单胺神经元，导致小鼠心理变化。
