Krivenko L E, Gel'tser B I
Ter Arkh. 1998;70(3):32-6.
Investigation of pulmonary ventilation, blood flow and cardiodynamics in subjects at risk of chronic nonspecific pulmonary disease (CNPD), prebronchitis (PB) and chronic bronchitis (CB).
118 workers exposed to toxico-chemical factors underwent zonal rheography.
At early stages of CB marked disorders of pulmonary ventilation and blood flow in the lungs were revealed. These disorders in subjects with threatened CNPD were regional and accompanied by a moderate increase in power inputs of the cardiorespiratory system. The maintenance of adequate pulmonary exchange in patients with PB entailed functional tension of the respiratory and cardiovascular systems that contributed to decompensation of adaptive mechanisms and occasionally to development of rheographic signs of pneumosclerosis in the lung zones with damaged ventilation and low perfusion of the pulmonary vessels.
Overloading and decompensation of respiratory and cardial mechanisms of gas exchange regulation in the lungs in response to external damage may lead to development of myocardiodystrophy and pneumosclerosis which appear to be the "price of adaptation".
研究慢性非特异性肺部疾病（CNPD）、支气管炎前期（PB）和慢性支气管炎（CB）高危人群的肺通气、血流和心脏动力学。
118名接触有毒化学因素的工人接受了分区血流图检查。
在CB早期，肺部出现明显的肺通气和血流紊乱。CNPD高危人群的这些紊乱是局部性的，并伴有心肺系统能量输入适度增加。PB患者维持足够的肺换气需要呼吸和心血管系统的功能紧张，这导致适应机制失代偿，偶尔会在通气受损和肺血管灌注不足的肺区出现肺硬化的血流图征象。
肺部气体交换调节的呼吸和心脏机制因外部损伤而负荷过重和失代偿，可能导致心肌营养不良和肺硬化的发展，这似乎是“适应的代价”。
