Gel'tser B I, Maĭdanov Iu V
Ter Arkh. 1997;69(3):9-12.
Lung surfactant (LS) was examined in the course of chronic bronchitis (CB) development in 25 subjects with CB risk factors (RF), 80 with prebronchitis (PB), 30 with chronic non-obstructive bronchitis (CNOB) and 45 with chronic obstructive bronchitis (COB). Biochemical study of the expirates covered total phospholipids (TP), fractions of neutral lipids, several fatty acids (FA), malonic dialdehyde (MDA), antiradical activity (ARA). Development of CB was accompanied with shifts in LS functional activity. In patients with RF the shifts reflected adaptation. In PB, CNOB and COB patients LS got damaged. The damage was detected by biochemical markers: elevated level of polyunsaturated FA, accumulation of MDA and low ARA.
对25名有慢性支气管炎（CB）危险因素（RF）的受试者、80名患支气管炎前期（PB）的患者、30名患慢性非阻塞性支气管炎（CNOB）的患者以及45名患慢性阻塞性支气管炎（COB）的患者，在慢性支气管炎发展过程中对肺表面活性物质（LS）进行了检测。对呼出气的生化研究涵盖了总磷脂（TP）、中性脂质组分、几种脂肪酸（FA）、丙二醛（MDA）、抗自由基活性（ARA）。慢性支气管炎的发展伴随着肺表面活性物质功能活性的变化。有危险因素的患者其变化反映为适应性变化。在支气管炎前期、慢性非阻塞性支气管炎和慢性阻塞性支气管炎患者中，肺表面活性物质受到损害。通过生化指标检测到这种损害：多不饱和脂肪酸水平升高、丙二醛蓄积以及抗自由基活性降低。
