Krasnov M M
Klin Monbl Augenheilkd. 1976 May;168(05):651-4.
Biological, rather then purely technical approach seems to be very essential to ensure better results in alloplasty of the cornea. The diseased corneal tissue (especially, after corneal burns) usually fails to accept a keratoprosthesis permanently. The cornea must, therefore, be biologically reconstructed by transplantation of autogenous tissue. Autogenous fascia lata, periosteum, sclera and auricular cartilage have been tried in the present work to surve the purpose. Autogenous sclera and cartilage proved to be best materials, the latter having an important advantage of being easily obtainable. Experimental studies (including hystological control) proved the method of "Chondrokeratoplasty" to be well founded. During the past four years the method has been used on the eyes of 18 patients with most severe corneal lesions unmanageable by the usual graft technique. The Keratoprosthesis must be buried under the cartilage disk until the adequate nutrition is developed and full vitality of the graft is achieved. Only then the cartilage disk is trephined in its centre and the optical part of the keratoprosthesis is exposed. Technically, the procedure is much simpler as compared to the procedure of odonto-keratoprosthesis by strampelly. The results seem to be highly encouraging. So far there was no extrusion after chondrokeratoprosthesis procedure.
对于角膜异体移植术而言,生物学方法而非单纯的技术方法似乎对确保更好的效果至关重要。患病的角膜组织(尤其是角膜烧伤后)通常无法永久接受角膜假体。因此,必须通过自体组织移植对角膜进行生物学重建。在本研究中,已尝试使用自体阔筋膜、骨膜、巩膜和耳廓软骨来达到此目的。自体巩膜和软骨被证明是最佳材料,后者具有易于获取的重要优势。实验研究(包括组织学对照)证明“软骨角膜成形术”方法有充分依据。在过去四年中,该方法已应用于18例患有最严重角膜病变且常规移植技术无法处理的患者的眼睛。角膜假体必须埋在软骨盘下,直到形成足够的营养供应并使移植物充分恢复活力。只有到那时,才在软骨盘中心打孔,露出角膜假体的光学部分。从技术上讲,与斯特兰佩利的牙-角膜假体手术相比,该手术要简单得多。结果似乎非常令人鼓舞。到目前为止,软骨角膜成形术后尚未出现排斥现象。