Brand F N, Larson M G, Kannel W B, McGuirk J M
Framingham Heart Study, Section of Preventative Medicine and Epidemiology, Boston University, School of Medicine, MA 01702, USA.
Vasc Med. 1997 Nov;2(4):296-301. doi: 10.1177/1358863X9700200404.
The prevalence and predisposing conditions for primary and secondary Raynaud's phenomenon (RP) were examined in The Framingham Study based on 16 years of follow-up of a cohort of 4182 men and women. The association with atypical chest pain and migraine headache was also investigated. Over the 16 years of follow-up there were 130 men and 171 women who developed primary RP. The prevalence in women (9.6%) was somewhat higher than in men (8.1%) and 81.4% of the RP was primary. Secondary RP was equally prevalent in men (18.6%) and women (19.7%). The most common causes of secondary RP were beta-blocker use (34.2%), carpal tunnel syndrome (10.5%) and rheumatoid arthritis (7.2%). Primary RP cases differed from noncases by having lower systolic blood pressure (p < or = 0.001) and diastolic blood pressure (p < 0.0001), and more coronary disease (p = 0.009), smoking (p < or = 0.01) and higher blood sugars (p < or = 0.009). Atypical chest pain was present more often than noted previously in The Framingham Study general population survey, and was equally prevalent in primary and secondary RP and in the two sexes. Associated migraine was more prevalent in women (14.4%) than men (5.0%). Vibrating tool use with associated RP occurred in 14.6%.
在弗明汉姆研究中，基于对4182名男性和女性队列长达16年的随访，对原发性和继发性雷诺现象（RP）的患病率及诱发因素进行了研究。同时还调查了其与非典型胸痛和偏头痛的关联。在16年的随访期内，有130名男性和171名女性患上了原发性RP。女性的患病率（9.6%）略高于男性（8.1%），且81.4%的RP为原发性。继发性RP在男性（18.6%）和女性（19.7%）中的患病率相当。继发性RP最常见的病因是使用β受体阻滞剂（34.2%）、腕管综合征（10.5%）和类风湿关节炎（7.2%）。原发性RP患者与未患病者相比，收缩压（p≤0.001）和舒张压（p＜0.0001）更低，冠心病（p = 0.009）、吸烟（p≤0.01）更多，血糖更高（p≤0.009）。非典型胸痛的出现频率高于弗明汉姆研究之前普通人群调查中的记录，在原发性和继发性RP以及两性中患病率相当。偏头痛在女性（14.4%）中比男性（5.0%）更常见。使用振动工具并伴有RP的情况占14.6%。
