[人类心血管疾病中心肌蛋白质的二维电泳]
[Two-dimensional electrophoresis of myocardial proteins in human cardio-vascular diseases].
作者信息
Kovalev L I, Severin V V, Ershova E S, Lukashova I V, Kovaleva M A, Shishkin S S
机构信息
Institute of Transplantology and Artificial Organs, RF Ministry of Health Moscow.
出版信息
Vopr Med Khim. 1998 Jan-Feb;44(1):106-10.
The protein composition of human myocardium at some cardiovascular pathologies was studied by use of 2D electrophoresis. It was found that dilitation(al) cardiomyopathy and ischemia are both characterized by transferrin accumulation in myocardium and by enhanced expression of a protein with Mm 3 kD/pI 5. Besides that, at ischemic disease there was seen an elevation of the fetal isoform in the light chain of myosin. For one of the polymorphous protein systems, the occurrence rate changes were also recorded.
利用二维电泳研究了某些心血管疾病状态下人类心肌的蛋白质组成。发现扩张型心肌病和局部缺血均表现为心肌中转铁蛋白的积累以及一种分子量为3 kD/等电点为5的蛋白质表达增强。除此之外，在缺血性疾病中还观察到肌球蛋白轻链中胎儿异构体的升高。对于其中一个多态蛋白质系统，也记录到了发生率的变化。
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