[碳酸锂与Contemnol在预防情感性和分裂情感性精神病中的疗效]

[The efficacy of lithium carbonate and Contemnol in preventing affective and schizoaffective psychoses].

作者信息

Mosolov S N, Kostiukova E G, Kuzavkova M V

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1998;98(3):15-8.

Abstract

Two groups of patients (30 patients in each group) were treated by lithium carbonate and contemnol. High preventive efficiency of both drugs was found: average annual duration of manic and depressive exacerbation as well as their frequency decreased practically by equal value--40-50%. The efficiency was somewhat higher in the group of patients treated by contemnol (80%) as compared with the group on lithium carbonate (70%). Total number of side-effects and spontaneous complaints was twice as much in prophylaxis by lithium carbonate. Wide application of contemnol in psychiatric practice for prophylaxis of aggravations (fits) of affective and schizoaffective psychoses is recommended.

摘要

两组患者（每组30例）分别接受碳酸锂和氯氮平治疗。发现两种药物均具有较高的预防效果：躁狂和抑郁发作的平均年持续时间及其频率实际上降低了相同的值——40% - 50%。与接受碳酸锂治疗的组（70%）相比，接受氯氮平治疗的组患者的有效率略高（80%）。碳酸锂预防时副作用和自发主诉的总数是氯氮平的两倍。建议在精神科实践中广泛应用氯氮平预防情感性和分裂情感性精神病的病情加重（发作）。