Nakata A, Takata S, Yuasa T, Shimakura A, Maruyama M, Nagai H, Sakagami S, Kobayashi K
First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Am J Physiol. 1998 Apr;274(4):H1211-7. doi: 10.1152/ajpheart.1998.274.4.H1211.
We investigated the frequency components of fluctuations in heart rate, arterial pressure, respiration, and muscle sympathetic nerve activity (MSNA) in 11 healthy women using an autoregressive model and examined the relation among variables using Akaike's relative power contribution analysis with multivariate autoregressive model fitting. Power spectral analysis of MSNA revealed two peaks, with low-frequency (LF) and high-frequency (HF) components. The LF component of MSNA was a major determinant of the LF component of arterial pressure and R-R interval variability (0.70 +/- 0.07 and 0.18 +/- 0.05, respectively). The effect of the LF component of MSNA on arterial pressure showed no change in response to propranolol but was diminished (0.35 +/- 0.08) by phentolamine (P < 0.02). The effect of the LF component of MSNA on R-R interval was not altered by pharmacological sympathetic nerve blockade. The HF component of MSNA did not influence other variables but was influenced by R-R interval, arterial pressure, and respiration. These findings indicate that the LF component of MSNA reflects autonomic oscillations, whereas the HF component is passive and influenced by other cardiovascular variables.
我们使用自回归模型研究了11名健康女性心率、动脉压、呼吸和肌肉交感神经活动（MSNA）波动的频率成分，并通过多元自回归模型拟合的赤池相对功率贡献分析来检验变量之间的关系。MSNA的功率谱分析显示有两个峰值，即低频（LF）和高频（HF）成分。MSNA的LF成分是动脉压和R-R间期变异性LF成分的主要决定因素（分别为0.70±0.07和0.18±0.05）。MSNA的LF成分对动脉压的影响在使用普萘洛尔后无变化，但在使用酚妥拉明后减弱（0.35±0.08）（P<0.02）。MSNA的LF成分对R-R间期的影响不受药理学交感神经阻滞的改变。MSNA的HF成分不影响其他变量，但受R-R间期、动脉压和呼吸的影响。这些发现表明，MSNA的LF成分反映自主神经振荡，而HF成分是被动的，受其他心血管变量影响。
