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Pure red cell aplasia due to persistent B19 parvovirus infection in patient infected with human immunodeficiency virus type 1. Recovery with alpha-interferon therapy.

作者信息

Martins A, Costa A, Oliveira M J, Rodrigues M, Ribeiro A P, Silvestre F, Reis A

机构信息

Medicine (Medicina 1 and Haematology Services) Department, Hospital Geral de Santo Antonio, Porto, Portugal.

出版信息

Sangre (Barc). 1998 Feb;43(1):67-9.

PMID:9577184
Abstract

B19 parvovirus (PV) infection is ordinarily resolved with the production of specific antibodies that neutralize virus infectivity for erythroid host cells. Nevertheless persistent infection with B19 PV and pure red blood cell aplasia have been documented. A 27 year-old male. i.v. drug abuser, HIV+ and HCV was diagnosed of pure red cell aplasia. Six months later we had serologic evidence of persistent parvovirus infection. Interferon therapy, started for HCV infection, showed a marked improvement of anaemia and anti parvovirus IgM became negative. It is discussed the possible role of interferon therapy in persistent parvovirus infection.

摘要

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