Nezu M, Oh H, Cho R, Sato H, Ikegami T, Yokota A, Nakaseko C, Nishimura M, Matsuura Y, Morio S, Hiruma K, Nakamura H, Asai T
Second Department of Internal Medicine, Chiba University, School of Medicine.
Rinsho Ketsueki. 1996 Feb;37(2):158-60.
A 46-year-old man with idiopathic thrombocytopenic purpura (ITP) refractory to corticosteroid, splenectomy and other drugs was admitted to our hospital in August, 1994, because of aseptic necrosis of the right femoral head. Although high-dose intravenous gamma-globulin was ineffective, the platelet count was increased within two weeks by the combination therapy that consisted of 0.02 mg/kg vincristine alternating with 0.1 mg/kg vinblastine by slow infusion at a 1-week interval, and oral 1.5 mg/day colchicine. He subsequently underwent the femoral head replacement. This combination therapy seems to be useful for refractory ITP in preparation for surgery.
一名46岁男性，患有特发性血小板减少性紫癜（ITP），对皮质类固醇、脾切除术及其他药物治疗均无效，因右股骨头无菌性坏死于1994年8月入住我院。尽管大剂量静脉注射丙种球蛋白无效，但通过每周间隔缓慢输注0.02mg/kg长春新碱与0.1mg/kg长春花碱交替使用，以及口服1.5mg/天秋水仙碱的联合治疗，血小板计数在两周内有所增加。随后他接受了股骨头置换术。这种联合治疗似乎对难治性ITP患者术前准备有用。
