[体外冲击波碎石术后尿路结石患者的脂质过氧化与抗氧化系统]
[Lipid peroxidation and the antioxidant system of patients with urolithiasis after extracorporeal lithotripsy].
作者信息
Golovanov S A, Ianenko E K, Dzeranov N K, Drozhzheva V V, Beĭshliev D A, Kon'kova T A
出版信息
Urol Nefrol (Mosk). 1998 Mar-Apr(2):14-6.
Activity of superoxide dismutase (SOD) in red cell membranes, levels of malonic dialdehyde (MDA) and dienic conjugates (DC) in blood plasma, red cells and urine were studied in 53 nephrolithiasis patients. A session of extracorporeal shock wave lithotripsy stimulated lipid peroxidation (LPO) in renal parenchyma manifesting with increased DC excretion with urine (an 89% increase). In red cell membranes SOD activity fell by 18%, DMA concentration rose by 16%. A two-week intake of vitamin E in a dose 100 mg/day elevated plasma alpha-tocopherol, diminished plasma MDA by 55% and prevented LPO activation in red cell membranes and renal parenchyma.
对53例肾结石患者的红细胞膜中超氧化物歧化酶（SOD）活性、血浆、红细胞和尿液中的丙二醛（MDA）及二烯共轭物（DC）水平进行了研究。一次体外冲击波碎石术刺激了肾实质中的脂质过氧化（LPO），表现为尿中DC排泄增加（增加了89%）。红细胞膜中的SOD活性下降了18%，DMA浓度上升了16%。连续两周每天服用100毫克维生素E可提高血浆α-生育酚水平，使血浆MDA减少55%，并防止红细胞膜和肾实质中的LPO激活。
Zotero 插件