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[华支睾吸虫病发病机制中细胞膜的功能失稳]

[Functional destabilization of the cell membranes in the pathogenesis of opisthorchiasis].

作者信息

Nalobin A V, Zhmurov V A, Nalobin V A, Liaĭkht E I

出版信息

Med Parazitol (Mosk). 1991 Mar-Apr(2):13-5.

PMID:2067485
Abstract

Lipid peroxidation (LPO) and antioxidant system have been studied in 28 patients with acute opisthorchiasis, 129 patients with chronic opisthorchiasis, 57 patients in the residual stage of the disease (6-12 months later) and 28 practically healthy subjects. The data obtained indicate excessive accumulation of primary (diene conjugates), secondary (malonic dialdehyde) and terminal (Schiff bases) LPO products in erythrocyte membranes of patients with acute and chronic opisthorchiasis. These patients have also revealed a drop in alpha-tocopherol level in erythrocyte membranes and blood plasma. An excessive content of primary and terminal LPO products persisted in erythrocyte membranes in the residual stage of the disease. Blood plasma alpha-tocopherol level remained low.

摘要

对28例急性后睾吸虫病患者、129例慢性后睾吸虫病患者、57例疾病残留期患者(6 - 12个月后)以及28名实际健康受试者的脂质过氧化(LPO)和抗氧化系统进行了研究。所获数据表明,急性和慢性后睾吸虫病患者红细胞膜中初级(二烯共轭物)、次级(丙二醛)和终末(席夫碱)LPO产物过度积累。这些患者还表现出红细胞膜和血浆中α - 生育酚水平下降。在疾病残留期,红细胞膜中初级和终末LPO产物含量仍然过高。血浆α - 生育酚水平依然较低。

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