King C E, Toskes P P
Major Probl Clin Surg. 1976;20:129-46.
We have tried to stress the complexity of the bacterial ecology that may exist in the intestine of patients and experimental animals with small intestinal bacterial overgrowth. The multiplicity of organisms often makes the management of these patients quite frustrating. A number of metabolic derangements of varying severity may occur in any given patient. Although many of the observed abnormalities are secondary to disturbed events with the luminal environment of the small intestine, the significance of direct damage to the small intestinal epithelium has been emphasized. Since intestinal cultures are both cumbersome and difficult to perform on a routine basis, the use of labeled substrate breath tests will allow guided, outpatient therapy more easily than in the past. Since full correction of the malabsorption is seldom achieved with antibiotic therapy, nutritional supplementation deserves more attention than it has previously received.
我们试图强调小肠细菌过度生长患者及实验动物肠道中可能存在的细菌生态复杂性。多种微生物的存在常常使这些患者的治疗颇具挫折感。在任何特定患者身上，可能会出现多种严重程度各异的代谢紊乱。尽管许多观察到的异常是小肠腔内环境紊乱事件的继发结果，但小肠上皮直接损伤的重要性也已得到强调。由于肠道培养既繁琐又难以常规进行，与过去相比，使用标记底物呼气试验将更便于进行有针对性的门诊治疗。由于抗生素治疗很少能完全纠正吸收不良，营养补充应得到比以往更多的关注。
