Candore G, Romano G C, D'Anna C, Di Lorenzo G, Gervasi F, Lio D, Modica M A, Potestio M, Caruso C
Istituti di Patologia Generale, Università di Palermo, Italia.
Pathobiology. 1998;66(1):33-7. doi: 10.1159/000027992.
The factors influencing the evolution of human immunodeficiency virus (HIV) infection are not fully known, but the host genotype undoubtedly plays a role in determining the outcome of the disease by affecting the immune response to HIV. The role of the host human leukocyte antigen (HLA) genotype in the regulation of susceptibility to HIV infection and expression has been studied extensively in different major risk groups. Certain HLA alleles and haplotypes, being associated with aberrant immune responses independently from HIV infection, have been reported to facilitate the rapid progression of disorders related to HIV infection. Particularly, the association of rapid acquired immunodeficiency syndrome (AIDS) progression with genes from the HLA-B8,DR3 haplotype has been reported by different research groups. It is well known that this haplotype is associated in all Caucasian populations with a wide variety of diseases with autoimmune features and in healthy subjects with a number of immune system dysfunctions, as a reduced production of T helper (Th)1 type cytokine. HIV infection may act on this genetic background triggering immunopathogenetic mechanisms leading to AIDS with a dominant Th2 profile as a common feature.
影响人类免疫缺陷病毒（HIV）感染演变的因素尚未完全明确，但宿主基因型无疑在通过影响对HIV的免疫反应来决定疾病转归方面发挥作用。宿主人类白细胞抗原（HLA）基因型在调节对HIV感染的易感性和表达方面的作用，已在不同主要风险群体中得到广泛研究。某些HLA等位基因和单倍型，与独立于HIV感染的异常免疫反应相关，据报道可促进与HIV感染相关疾病的快速进展。特别是，不同研究小组都报道了快速获得性免疫缺陷综合征（AIDS）进展与HLA-B8、DR3单倍型基因之间的关联。众所周知，在所有白种人群体中，这种单倍型与多种具有自身免疫特征的疾病相关，在健康受试者中与一些免疫系统功能障碍相关，如T辅助（Th）1型细胞因子产生减少。HIV感染可能作用于这一遗传背景，触发免疫发病机制，导致以Th2型为主导特征的AIDS。
