Bychkova N V, Meshkova I E, Pozharisskiĭ K M
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, Center of Emergency and Radiation Medicine, St. Petersburg.
Vopr Onkol. 1998;44(1):54-9.
Flow cytometry was used for measure DNA content of tumor cells of squamous-cell carcinoma of the tongue and mucosa of the oral cavity fundus, invasive ductal breast carcinoma, endometrial, colonic and rectal adenocarcinomas. Frequency of aneuploidy is characteristic of tumor. Frequency of aneuploidy is high in the oral cavity and breast cancer, colonic and rectal carcinomas and low in cancer of the tongue and endometrium Aneuploidy is associated with nonfavorable clinical and morphological signs of breast cancer, carcinomas of the oral cavity, corpurus uteri and rectum. High DNA index is typical of aggressiveness of carcinomas of the tongue, breast and endometrium. High proliferative activity prognostic factor of endometrial adenocarcinoma. We also found aneuploid cells in normal epithelium of the corpurus uteri, colon and rectum of patients with aneuploid tumors of the same organ. It is possible to suggest that these cells is an unfavorable cause recurrence.
流式细胞术用于测量舌鳞状细胞癌、口腔底部黏膜癌、浸润性导管乳腺癌、子宫内膜癌、结肠和直肠腺癌的肿瘤细胞的DNA含量。非整倍体频率是肿瘤的特征。口腔癌和乳腺癌、结肠癌和直肠癌的非整倍体频率高，而舌癌和子宫内膜癌的非整倍体频率低。非整倍体与乳腺癌、口腔癌、子宫癌和直肠癌的不良临床和形态学体征相关。高DNA指数是舌癌、乳腺癌和子宫内膜癌侵袭性的典型特征。高增殖活性是子宫内膜腺癌的预后因素。我们还在同一器官发生非整倍体肿瘤的患者的子宫、结肠和直肠的正常上皮中发现了非整倍体细胞。有可能提示这些细胞是复发的不利原因。
