Stukov A N, Mironiuk T N, Kon'kov S A, Krylova I M, Reztsova V V, Filov V A, Ivin B A
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Vopr Onkol. 1998;44(1):100-2.
In experiments using mice and rats with transplantable Ehrlich ascites tumors, sarcoma-180 and adenocarcinoma of Walker, antitumor activity of doxorubicin in combination with disodium salt of 1,1-methylenediphosphonic acid proved higher than that of doxorubicin alone. Most advantage was gained with daily treatment. The toxic effect of said complex treatment seemed to differ slightly from that of doxorubicin as judged on the basis of survival, changes in body mass and peripheral blood count.
在使用患有可移植性艾氏腹水瘤、肉瘤-180和沃克腺癌的小鼠和大鼠进行的实验中，阿霉素与1,1-亚甲基二膦酸二钠盐联合使用时的抗肿瘤活性证明高于单独使用阿霉素。每日治疗效果最佳。根据存活率、体重变化和外周血细胞计数判断，上述联合治疗的毒性作用似乎与阿霉素略有不同。
