Josefsson M, Becker M, Stroman F, Brenner D G, Petersson G
Department of Otorhinolaryngology, Malmö University Hospital, Sweden.
Am J Rhinol. 1998 Mar-Apr;12(2):135-41. doi: 10.2500/105065898781390244.
The nasal mucosa harbors sensory nerves containing neuropeptides such as substance P (SP), which are released by capsaicin. The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa. We studied the effect of enzymatically active recombinant NEP (rNEP) on neuropeptide-evoked secretion of nasal fluid and plasma exudation in rats. rNEP administered intranasally (i.n.) reduced the capsaicin-evoked nasal fluid secretion but failed to reduce the secretion evoked by SP (exogenous) under the experimental conditions used. rNEP reduced the increase in nasal plasma exudation evoked by capsaicin (endogenous neuropeptides). Because rNEP reduced neuropeptide-mediated nasal fluid secretion and plasma exudation in the rat, we suggest that peptidase activity in the nasal mucosa will determine the magnitude of the response to locally released neuropeptides.
鼻黏膜含有感觉神经，这些神经含有诸如P物质（SP）等神经肽，它们可被辣椒素释放。神经肽由肽酶降解，例如存在于鼻黏膜中的中性内肽酶（NEP）。我们研究了具有酶活性的重组NEP（rNEP）对大鼠神经肽诱发的鼻液分泌和血浆渗出的影响。在所用实验条件下，经鼻内（i.n.）给予rNEP可减少辣椒素诱发的鼻液分泌，但未能减少外源性SP诱发的分泌。rNEP减少了辣椒素（内源性神经肽）诱发的鼻血浆渗出增加。由于rNEP减少了大鼠中神经肽介导的鼻液分泌和血浆渗出，我们认为鼻黏膜中的肽酶活性将决定对局部释放的神经肽的反应程度。
