Yoshida K, Higuchi H, Hishikawa Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Clin Neuropharmacol. 1998 Jan-Feb;21(1):68-9.
We report on a schizophrenic patient whose tardive dystonia, delusions, and auditory hallucinations showed remarkable concurrent improvement after replacing haloperidol with risperidone. The present finding suggests that the 5-hydroxytryptamine-2 (5-HT2) antagonistic action of risperidone has brought about the improvement in tardive dystonia. The 5-HT2 antagonistic action of risperidone, in addition to its dopamine antagonistic action, may have also lessened psychotic symptoms in the current case.
我们报告了一名精神分裂症患者，在用利培酮替代氟哌啶醇后，其迟发性肌张力障碍、妄想和幻听同时有显著改善。目前的发现表明，利培酮的5-羟色胺-2（5-HT2）拮抗作用带来了迟发性肌张力障碍的改善。利培酮的5-HT2拮抗作用，除了其多巴胺拮抗作用外，在当前病例中可能也减轻了精神病症状。
