Martín-Esteban M, García-Ara M C, Banqué-Molas M, Boyano-Martínez M T, Martín-Muñoz F, Díaz-Pena J M
Allergy Service, Hospital Infantil Universitario La Paz, Madrid, Spain.
J Pediatr Gastroenterol Nutr. 1998 Apr;26(4):398-401. doi: 10.1097/00005176-199804000-00007.
Hydrolysate formulas are safe for most infants who are allergic to cow's milk. The purpose of this study was to assess the clinical tolerance and safety of an extensively hydrolyzed casein-whey protein formula in a homogeneous group of patients with immediate cow's milk hypersensitivity.
The study population consisted of 33 infants in whom immediate cow's milk protein allergy had been diagnosed by clinical data, evidence of specific immunoglobulin E antibodies, and positive results in a controlled challenge test with cow's milk proteins.
The hydrolysate was well tolerated in 31 of the 33 patients, which represented a 94% effectiveness. Using 95% confidence intervals generated for a binomial outcome (reaction-no reaction), the casein-whey protein formula is tolerated by 84.4% to 99% of infants with immediate immunoglobulinE-mediated cow's milk protein allergy. These figures are in the range of values recommended for this type of product.
This extensively hydrolyzed casein-whey protein formula is generally safe to feed children with immediate hypersensitivity to cow's milk. However. it is advisable that the first intakes be given under direct medical supervision, in that the occurrence of adverse reactions in highly sensitive infants cannot be unequivocally excluded.
水解配方奶粉对大多数牛奶过敏的婴儿是安全的。本研究的目的是评估一种深度水解酪蛋白-乳清蛋白配方奶粉在一组患有速发型牛奶过敏的同质患者中的临床耐受性和安全性。
研究人群包括33名婴儿，他们通过临床数据、特异性免疫球蛋白E抗体证据以及牛奶蛋白激发试验阳性结果被诊断为速发型牛奶蛋白过敏。
33名患者中有31名对水解配方奶粉耐受性良好，有效率为94%。使用二项式结果（有反应-无反应）生成的95%置信区间，酪蛋白-乳清蛋白配方奶粉被84.4%至99%的速发型免疫球蛋白E介导的牛奶蛋白过敏婴儿耐受。这些数字在这类产品推荐的范围内。
这种深度水解酪蛋白-乳清蛋白配方奶粉通常对牛奶速发型过敏的儿童喂养是安全的。然而，建议首次喂食在直接医疗监督下进行，因为不能明确排除高度敏感婴儿出现不良反应的可能性。
