Yáñez A M, Peleteiro-Ramos R, Camba M A, Yaksh T L
Servicio de Anestesia-Reanimación y Clínica del Dolor, Complejo Hospitalario A. Marcide, El Ferrol, La Coruña.
Rev Esp Anestesiol Reanim. 1998 Jan;45(1):17-23.
Repeated C fiber stimulation results in increased spinal afferent processing leading to exaggerated response to a painful stimulus (hyperalgesia) and anomalous pain behavior in response to an otherwise innocuous stimulus (allodynia). Evidence points to a complex scenario in which continued C fiber stimulation leads to local spinal release of glutamate, which activates spinal N-methyl-D-aspartate receptors. Their activation then leads to increased intracellular Ca and later to spinal formation of several intermediaries, including prostanoids and nitric oxide. Both serve to facilitate spinal processing directly, by increasing the release of spinal neurotransmitters. Conversely, spinal delivery of antagonists of such processes prevents a hyperalgesixc state from developing. These observations are clearly relevant to the study and management of pain following injury in humans.
重复刺激C纤维会导致脊髓传入处理增强，从而对疼痛刺激产生夸张反应（痛觉过敏），并对原本无害的刺激产生异常疼痛行为（异常性疼痛）。有证据表明存在一种复杂的情况，持续的C纤维刺激会导致脊髓局部释放谷氨酸，进而激活脊髓N-甲基-D-天冬氨酸受体。这些受体的激活随后会导致细胞内钙离子增加，随后在脊髓中形成多种介质，包括前列腺素和一氧化氮。两者都通过增加脊髓神经递质的释放直接促进脊髓处理。相反，对此类过程的拮抗剂进行脊髓给药可防止痛觉过敏状态的发展。这些观察结果显然与人类受伤后疼痛的研究和管理相关。
