Plueckhahn V D, Collins R B
Med J Aust. 1976 May 29;1(22):815-9.
This paper reviews 81,756 live births and 858 infant deaths occurring during the years 1959 to 1969. Sixty-three instances of central nervous system vacuolation are reported. Prematurity is shown to be a necessary prerequisite for central nervous system vacuolation to occur during routine antiseptic skin care of newborn infants with 3% hexachlorophene emulsions. Hyperbilirubinaemia is a contributory factor in such premature infants. Long-term clinical follow-up studies show that, should central nervous system vacuolation occur in premature infants, there is no resultant detriment to their immediate clinical progress and physical and neurological development. Normal newborn infants weighing more than 2,000 g do not develop such central nervous system vacuolation during routine antiseptic skin care. The writers conclude that there is no rationale for regulations to restrict the use of 3% hexachlorophene emulsions in routine antiseptic skin care of normal newborn infants and that the benefits of such use far outweigh any possible risks from central nervous system vacuolation.
本文回顾了1959年至1969年间的81,756例活产婴儿和858例婴儿死亡情况。报告了63例中枢神经系统空泡化病例。研究表明，在使用3%六氯酚乳剂对新生儿进行常规皮肤消毒护理时，早产是中枢神经系统空泡化发生的必要前提条件。高胆红素血症是此类早产儿的一个促成因素。长期临床随访研究表明，如果早产儿发生中枢神经系统空泡化，不会对其即时临床进展以及身体和神经发育造成损害。体重超过2000克的正常新生儿在常规皮肤消毒护理期间不会出现此类中枢神经系统空泡化。作者得出结论，没有理由制定法规限制在正常新生儿常规皮肤消毒护理中使用3%六氯酚乳剂，而且这种使用的益处远远超过中枢神经系统空泡化带来的任何可能风险。
