Laursen S B, Dreijer B, Hemmingsen C, Jacobsen E
Danish Respiratory Centre East, Department of Infectious Diseases, University of Copenhagen, Denmark.
Respiration. 1998;65(2):114-9. doi: 10.1159/000029241.
We evaluated the effect of non-invasive nocturnal ventilation with the bi-level positive airway pressure (BiPAP) ventilator in 12 overweight patients with verified obstructive sleep apnoea syndrome (OSAS) and nocturnal hypercapnia. All patients exhibited subsequently less overnight CO2 accumulation (p < 0.0001), the desaturation event frequency was reduced (p < 0.002), daytime O2 tension rose (p < 0.001), daytime CO2 tension was reduced (p < 0.01), and apnoeas were eliminated. All symptoms characterising the syndrome, when present at the beginning of the therapy, were eliminated during the treatment. Patient compliance was high. This study showed that OSAS patients with hypercapnia can be effectively treated by BiPAP ventilation during sleep.
我们评估了双水平气道正压通气（BiPAP）呼吸机进行无创夜间通气对12例确诊为阻塞性睡眠呼吸暂停综合征（OSAS）且伴有夜间高碳酸血症的超重患者的影响。所有患者随后夜间二氧化碳蓄积均减少（p<0.0001），低氧血症事件频率降低（p<0.002），日间氧分压升高（p<0.001），日间二氧化碳分压降低（p<0.01），且呼吸暂停消失。治疗开始时存在的该综合征的所有症状在治疗期间均消失。患者依从性高。本研究表明，伴有高碳酸血症的OSAS患者在睡眠期间通过BiPAP通气可得到有效治疗。
