Vega M, Devoto L
Institute of the Mother and Child Research, Santiago, Chile.
Semin Reprod Endocrinol. 1997;15(4):353-62. doi: 10.1055/s-2008-1068373.
The human corpus luteum (CL) is a transient endocrine gland regulated primarily by the age-dependent action of LH/hCG, which initiates a series of cell-specific processes necessary for the structure and also function of the gland. An extensive local regulation of the luteal function also exists, based on the heterogeneity of the cellular composition of the CL. It is most likely that interactions occur among the different subpopulations of steroidogenic (large and small luteal cells) and nonsteroidogenic cells (leukocytes, endothelial cells, and fibroblasts). Therefore, local produced substances, including steroids, growth factors, reactive oxygen species, and, recently, nitric oxide, may modulate luteal life span. The knowledge of the basic events involved in the control of human luteal function may lead to a better understanding of the physiopathology of the human menstrual cycle.
人类黄体（CL）是一种短暂存在的内分泌腺，主要受促黄体生成素/人绒毛膜促性腺激素（LH/hCG）随年龄变化的作用调节，LH/hCG启动了该腺体结构和功能所需的一系列细胞特异性过程。基于黄体细胞组成的异质性，黄体功能也存在广泛的局部调节。类固醇生成细胞（大、小黄体细胞）和非类固醇生成细胞（白细胞、内皮细胞和成纤维细胞）的不同亚群之间很可能发生相互作用。因此，包括类固醇、生长因子、活性氧，以及最近发现的一氧化氮在内的局部产生的物质，可能会调节黄体寿命。了解人类黄体功能控制所涉及的基本事件，可能有助于更好地理解人类月经周期的生理病理学。
