Del Vecchio R P
Agriculture and Agri-Food Canada, Brandon Research Center, Manitoba.
Semin Reprod Endocrinol. 1997;15(4):409-20. doi: 10.1055/s-2008-1068378.
The corpus luteum is an extremely important reproductive endocrine gland that influences numerous physiological processes and is therefore perhaps the most widely studied reproductive endocrine structure to date. The corpus luteum and its major product, progesterone, are central to any discussion of impaired reproductive performance. It is generally agreed that our best chances for reducing reproductive losses lie in a thorough understanding of the mechanisms controlling luteal function during reproductive cycles and pregnancy. Normal corpus luteum function is dependent on numerous regulatory factors, such as prostaglandins, oxytocin, steroids, growth factors, cytokines, etc. Recently, increased interest in studying luteal cell interactions (steroidogenic large and small luteal cells as well as nonsteroidogenic "accessory" cells of the corpus luteum) has produced new evidence of communication within the corpus luteum that influences its function. The exact means of communication among the luteal cells are not known; however, this interaction seems to involve both luteotropic and luteolytic actions and can occur through either contact-dependent and contact-independent mechanisms.
黄体是一个极其重要的生殖内分泌腺，它影响着众多生理过程，因此可能是迄今为止研究最为广泛的生殖内分泌结构。黄体及其主要产物孕酮，是任何关于生殖性能受损讨论的核心。人们普遍认为，我们减少生殖损失的最佳机会在于深入了解生殖周期和孕期控制黄体功能的机制。正常的黄体功能依赖于众多调节因子，如前列腺素、催产素、类固醇、生长因子、细胞因子等。最近，对黄体细胞相互作用（类固醇生成的大、小黄体细胞以及黄体的非类固醇生成“辅助”细胞）研究兴趣的增加，产生了影响黄体功能的黄体内部通讯的新证据。黄体细胞之间的确切通讯方式尚不清楚；然而，这种相互作用似乎涉及促黄体生成和黄体溶解作用，并且可以通过接触依赖性和非接触依赖性机制发生。
