Meidan R, Girsh E
Department of Animal Sciences, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Israel.
Semin Reprod Endocrinol. 1997;15(4):371-82. doi: 10.1055/s-2008-1068375.
The LH surge triggers the ovulation of the preovulatory follicle and subsequent formation of a corpus luteum. After ovulation, microvessels from the thecal layer grow into the granulosa cell layer and a rapid process of neovascularization takes place, by midcycle endothelial cells constitute more than 50% of total corpus luteum (CL) cells. Concomitantly with the angiogenic process, luteal steroidogenic cells differentiate as they are surrounded by the growing capillary network. Luteal regression, on the other hand, is accompanied by changes in blood flow and vasculature. Thus, changes in the endothelial cell population within the CL closely consort with the functional changes occurring during various stages of the CL life span. This article summarizes data demonstrating that endothelial cells play an essential role in luteal steroidogenic activity by being involved in both luteotrophic and luteolytic processes.
促黄体生成素峰触发排卵前卵泡排卵及随后黄体的形成。排卵后，来自卵泡膜层的微血管长入颗粒细胞层，快速的血管生成过程发生，到月经周期中期，内皮细胞占黄体（CL）细胞总数的50%以上。在血管生成过程中，黄体类固醇生成细胞随着被不断生长的毛细血管网络包围而分化。另一方面，黄体退化伴随着血流和脉管系统的变化。因此，黄体中内皮细胞群体的变化与黄体生命周期各个阶段发生的功能变化密切相关。本文总结的数据表明，内皮细胞通过参与黄体营养和黄体溶解过程，在黄体类固醇生成活性中发挥重要作用。
