Skrodzka D, Gabryelewicz A
Department of Gastroenterology, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1997;42(1):257-66.
The 24 patients with gastric ulcer were treated ranitidine (2 x 150 mg daily) or nocloprost (2 x 200 micrograms daily). The effects of these drugs on the gastric juice components were measured. We evaluated hydrochloric acid, total protein, pepsin and some carbohydrates components secretion. We showed, that ranitidine decreased significantly total protein, fucose, N-acetylneuraminic acid and hexoses contents in the gastric juice in the basal secretion; the same tendency was observed in the pentagastrin-stimulated secretion. The similar direction of the changes, but weakly expressed was confirmed in the patients treated with nocloprost. It has been shown, that ranitidine modified the gastric mucin components content, what can suggest diminished degradation of mucus directly adhering to the gastric mucosa.
24例胃溃疡患者接受雷尼替丁（每日2次，每次150毫克）或诺氯前列素（每日2次，每次200微克）治疗。测定了这些药物对胃液成分的影响。我们评估了盐酸、总蛋白、胃蛋白酶和一些碳水化合物成分的分泌。结果显示，雷尼替丁显著降低了基础分泌时胃液中总蛋白、岩藻糖、N-乙酰神经氨酸和己糖的含量；在五肽胃泌素刺激分泌时也观察到相同趋势。用诺氯前列素治疗的患者也证实了变化方向相似但表现较弱。研究表明，雷尼替丁改变了胃黏液成分的含量，这可能提示直接附着于胃黏膜的黏液降解减少。
Zotero 插件