通过随机搜索参与人类乳腺癌细胞抗雌激素耐药性的基因来鉴定BCAR3。
Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.
作者信息
van Agthoven T, van Agthoven T L, Dekker A, van der Spek P J, Vreede L, Dorssers L C
机构信息
Department of Molecular Biology, Daniel den Hoed Cancer Center, University Hospital Rotterdam, Rotterdam, The Netherlands.
出版信息
EMBO J. 1998 May 15;17(10):2799-808. doi: 10.1093/emboj/17.10.2799.
Abstract
The antiestrogen tamoxifen is important in the treatment of hormone-dependent breast cancer, although development of resistance is inevitable. To unravel the molecular mechanisms of antiestrogen resistance, a search for involved genes was initiated. Retrovirus-mediated insertional mutagenesis was applied to human ZR-75-1 breast cancer cells. Infected cells were subjected to tamoxifen selection and a panel of resistant cell clones was established. Screening for a common integration site resulted in the identification of a novel gene designated BCAR3. Transfer of this locus by cell fusion or transfection of the BCAR3 cDNA to ZR75-1 and MCF-7 cells induces antiestrogen resistance. BCAR3 represents a putative SH2 domain-containing protein and is partly homologous to the cell division cycle protein CDC48.
摘要
抗雌激素药物他莫昔芬在激素依赖性乳腺癌的治疗中具有重要作用，尽管耐药性的产生不可避免。为了阐明抗雌激素耐药的分子机制，人们开始寻找相关基因。逆转录病毒介导的插入诱变技术被应用于人类ZR-75-1乳腺癌细胞。对感染的细胞进行他莫昔芬筛选，建立了一组耐药细胞克隆。通过筛选共同整合位点，鉴定出一个名为BCAR3的新基因。通过细胞融合或将BCAR3 cDNA转染到ZR75-1和MCF-7细胞中转移该基因座可诱导抗雌激素耐药。BCAR3是一种推测含有SH2结构域的蛋白质，与细胞分裂周期蛋白CDC48部分同源。
相似文献
1
Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.通过随机搜索参与人类乳腺癌细胞抗雌激素耐药性的基因来鉴定BCAR3。
EMBO J. 1998 May 15;17(10):2799-808. doi: 10.1093/emboj/17.10.2799.
2
Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells.蛋白激酶Cα是抗雌激素耐药的标志物，且参与他莫昔芬耐药的人乳腺癌细胞的生长。
Breast Cancer Res Treat. 2007 Aug;104(2):165-79. doi: 10.1007/s10549-006-9399-1. Epub 2006 Oct 24.
3
Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway.由BCAR1或BCAR3基因介导的乳腺癌雌激素非依赖性是通过不同于雌激素受体信号通路或表皮生长因子受体信号通路的机制传递的。
Breast Cancer Res. 2005;7(1):R82-92. doi: 10.1186/bcr954. Epub 2004 Nov 16.
4
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site.利用缺陷型逆转录病毒通过随机插入诱变诱导人乳腺癌细胞产生抗雌激素耐药性：常见整合位点bcar-1的鉴定
Mol Endocrinol. 1993 Jul;7(7):870-8. doi: 10.1210/mend.7.7.8413311.
5
Selective recruitment of breast cancer anti-estrogen resistance genes and relevance for breast cancer progression and tamoxifen therapy response.选择性招募乳腺癌抗雌激素耐药基因及其与乳腺癌进展和他莫昔芬治疗反应的相关性。
Endocr Relat Cancer. 2010 Feb 18;17(1):215-30. doi: 10.1677/ERC-09-0062. Print 2010 Mar.
6
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.BCAR1，衔接蛋白p130Cas的人类同源物，与乳腺癌细胞中的抗雌激素耐药性
J Natl Cancer Inst. 2000 Jan 19;92(2):112-20. doi: 10.1093/jnci/92.2.112.
7
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.乳腺癌抗雌激素耐药基因在人类乳腺癌进展及他莫昔芬耐药中的相关性
J Clin Oncol. 2009 Feb 1;27(4):542-9. doi: 10.1200/JCO.2008.17.1462. Epub 2008 Dec 15.
8
Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells.他莫昔芬对乳腺癌细胞和子宫内膜癌细胞中人端粒酶逆转录酶（hTERT）基因表达的调控存在差异。
Oncogene. 2002 May 16;21(22):3517-24. doi: 10.1038/sj.onc.1205463.
9
p53 mutation and tamoxifen resistance in breast cancer.乳腺癌中的p53突变与他莫昔芬耐药性
Clin Cancer Res. 1995 Oct;1(10):1203-8.
10
Gene expression changes during the development of estrogen-independent and antiestrogen-resistant growth in breast cancer cell culture models.在乳腺癌细胞培养模型中，雌激素非依赖性和抗雌激素抗性生长发育过程中的基因表达变化。
Anticancer Drugs. 2009 Jan;20(1):51-8. doi: 10.1097/CAD.0b013e32831845e1.
引用本文的文献
1
and -related competing endogenous RNA expression in hepatocellular carcinoma and their prognostic value.肝细胞癌中与……相关的竞争性内源性RNA表达及其预后价值。 （注：原文“and -related”表述不完整，这里只能按现有内容尽量准确翻译）
World J Gastrointest Oncol. 2024 Jul 15;16(7):3082-3096. doi: 10.4251/wjgo.v16.i7.3082.
2
Deciphering the Role of BCAR3 in Cancer Progression: Gene Regulation, Signal Transduction, and Therapeutic Implications.解读BCAR3在癌症进展中的作用：基因调控、信号转导及治疗意义
Cancers (Basel). 2024 Apr 26;16(9):1674. doi: 10.3390/cancers16091674.
3
Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.SMYD2甲基转移酶诱导的细胞骨架重塑驱动乳腺癌转移。
Cell Discov. 2024 Jan 31;10(1):12. doi: 10.1038/s41421-023-00644-x.
4
CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles.CCIVR 有助于全面识别 cis-天然反义转录本及其结构特征和表达谱。
Sci Rep. 2022 Sep 15;12(1):15525. doi: 10.1038/s41598-022-19782-5.
5
Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.对 Luminal A 和 B 型乳腺癌亚型患者的 RET、BCAR1 和 BCAR3 表达进行全面的免疫组织化学分析。
Breast Cancer Res Treat. 2022 Feb;192(1):43-52. doi: 10.1007/s10549-021-06452-9. Epub 2022 Jan 15.
6
Breast Cancer Antiestrogen Resistance 3 (BCAR3) promotes tumor growth and progression in triple-negative breast cancer.乳腺癌抗雌激素耐药3（BCAR3）促进三阴性乳腺癌的肿瘤生长和进展。
Am J Cancer Res. 2021 Oct 15;11(10):4768-4787. eCollection 2021.
7
BCAR3 promotes head and neck cancer growth and is associated with poor prognosis.BCAR3促进头颈癌生长并与预后不良相关。
Cell Death Discov. 2021 Oct 27;7(1):316. doi: 10.1038/s41420-021-00714-7.
8
Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer.长链非编码 RNA-DC 促进乳腺癌的雌激素非依赖性生长和他莫昔芬耐药。
Cell Death Dis. 2021 Oct 25;12(11):1000. doi: 10.1038/s41419-021-04288-1.
9
A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics.Cas-BCAR3 共调控回路控制片状伪足动力学。
Elife. 2021 Jun 25;10:e67078. doi: 10.7554/eLife.67078.
10
Systematic Identification of circRNA-miRNA-mRNA Regulatory Network in Esophageal Squamous Cell Carcinoma.食管鳞状细胞癌中circRNA-miRNA-mRNA调控网络的系统鉴定
Front Genet. 2021 Mar 3;12:580390. doi: 10.3389/fgene.2021.580390. eCollection 2021.
本文引用的文献
1
Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells.通过细胞融合介导的基因转移在人乳腺癌细胞中鉴定一个新的乳腺癌抗雌激素抗性（BCAR2）基因座。
Int J Cancer. 1997 Aug 7;72(4):700-5. doi: 10.1002/(sici)1097-0215(19970807)72:4<700::aid-ijc24>3.0.co;2-d.
2
Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: influences of the ability of cells to migrate through the filter membrane.采用体外Boyden小室试验评估人妇科肿瘤细胞系的侵袭潜能：细胞穿过滤膜迁移能力的影响
Clin Exp Metastasis. 1997 Jan;15(1):53-62. doi: 10.1023/a:1018436407280.
3
Retroviral insertional mutagenesis as a strategy to identify cancer genes.逆转录病毒插入诱变作为一种识别癌症基因的策略。
Biochim Biophys Acta. 1996 May 16;1287(1):29-57. doi: 10.1016/0304-419x(95)00020-g.
4
Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.生长因子、类固醇及类固醇拮抗剂对细胞周期蛋白基因表达的调节与T-47D人乳腺癌细胞周期进程的变化相关。
Mol Cell Biol. 1993 Jun;13(6):3577-87. doi: 10.1128/mcb.13.6.3577-3587.1993.
5
Hormone resistance, invasiveness, and metastatic potential in breast cancer.乳腺癌中的激素抵抗、侵袭性和转移潜能。
Breast Cancer Res Treat. 1993;24(3):227-39. doi: 10.1007/BF01833263.
6
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site.利用缺陷型逆转录病毒通过随机插入诱变诱导人乳腺癌细胞产生抗雌激素耐药性：常见整合位点bcar-1的鉴定
Mol Endocrinol. 1993 Jul;7(7):870-8. doi: 10.1210/mend.7.7.8413311.
7
pS2 and response to adjuvant hormone therapy in primary breast cancer.pS2与原发性乳腺癌辅助激素治疗的反应
Br J Cancer. 1994 Feb;69(2):394-7. doi: 10.1038/bjc.1994.73.
8
Mechanisms of hormone resistance in breast cancer.乳腺癌中激素抵抗的机制。
Breast Cancer Res Treat. 1993;26(2):119-30. doi: 10.1007/BF00689685.
9
Biochemical characterization of valosin-containing protein, a protein tyrosine kinase substrate in hematopoietic cells.含缬酪肽蛋白的生化特性，一种造血细胞中的蛋白酪氨酸激酶底物。
J Biol Chem. 1994 Apr 15;269(15):11435-41.
10
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.鉴定出一种诱导侵袭的基因Tiam-1，该基因编码一种与Rho样蛋白的GDP-GTP交换因子具有同源性的蛋白质。
Cell. 1994 May 20;77(4):537-49. doi: 10.1016/0092-8674(94)90216-x.
Zotero 插件