尼古丁持续给药可增加小鼠脑中地西泮结合抑制剂（DBI）及其mRNA的水平。
Continuous treatment with nicotine increases diazepam binding inhibitor (DBI) and its mRNA in the mouse brain.
作者信息
Katsura M, Ohkuma S, Xu J, Hibino Y, Tsujimura A, Kuriyama K
机构信息
Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki 701-01, Japan.
出版信息
Brain Res Mol Brain Res. 1998 Apr;55(2):345-9. doi: 10.1016/s0169-328x(98)00019-9.
Effect of chronic treatment with nicotine on DBI and its mRNA in mouse cerebral cortex were examined. Continuous treatment of mice with nicotine significantly increased DBI content and its mRNA expression, which was completely abolished by simultaneous administration of mecamylamine (1 mg/kg, i.p.). These results indicate that chronic functional interaction between nicotine and nicotinic acetylcholine receptors has a critical role in increases in DBI content and its mRNA expression.
研究了尼古丁长期治疗对小鼠大脑皮质中DBI及其mRNA的影响。用尼古丁持续治疗小鼠可显著增加DBI含量及其mRNA表达，而同时给予美加明（1毫克/千克，腹腔注射）可完全消除这种增加。这些结果表明，尼古丁与烟碱型乙酰胆碱受体之间的长期功能相互作用在DBI含量及其mRNA表达的增加中起关键作用。
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