Katsura M, Hara A, Higo A, Tarumi C, Hibino Y, Ohkuma S
Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki, Japan.
J Neurochem. 1998 Dec;71(6):2638-41. doi: 10.1046/j.1471-4159.1998.71062638.x.
Effects of acute and chronic morphine treatment on the expression of diazepam binding inhibitor (DBI) mRNA in the mouse brain were examined. Cerebral DBI mRNA expression significantly increased in morphine-dependent mice, and this increase is more remarkable in morphine-withdrawn mice, whereas a single administration of morphine (50 mg/kg) produced no changes in the expression. Simultaneous administration of naloxone (3 mg/kg) with morphine completely abolished the increase in cerebral DBI mRNA expression observed in morphine-dependent and -withdrawn mice. These results indicate that a chronic functional interaction between morphine and opioid receptors has a critical role in increases in DBI mRNA expression.
研究了急性和慢性吗啡处理对小鼠脑中地西泮结合抑制剂（DBI）mRNA表达的影响。吗啡依赖小鼠脑内DBI mRNA表达显著增加，且这种增加在吗啡戒断小鼠中更明显，而单次给予吗啡（50 mg/kg）对表达无影响。纳洛酮（3 mg/kg）与吗啡同时给药完全消除了在吗啡依赖和戒断小鼠中观察到的脑内DBI mRNA表达增加。这些结果表明，吗啡与阿片受体之间的慢性功能相互作用在DBI mRNA表达增加中起关键作用。
