Ehrenreich T, Porush J G, Churg J, Garfinkel L, Glabman S, Goldstein M H, Grishman E, Yunis S L
N Engl J Med. 1976 Sep 30;295(14):741-6. doi: 10.1056/NEJM197609302951401.
In a retrospective study of the effect of treatment in biopsy-proved idiopathic membranous nephropathy, 91 adults and 12 children were followed for periods up to 29 years after clinical onset (mean, 6.5 years). Forty-four were treated with corticosteroids, 15 with corticosteroids and immunosuppressants; 44 had no treatment and served as a control group. Clinical cure and improvement were significantly greater in the treated than in the nontreated group (P less than 0.01). The recurrence rate, occurrence of renal failure and probability of death were significantly greater in the nontreated group, although some of these patients eventually showed improvement. Prognosis was better in patients who responded to therapy. These data strongly suggest that steroid therapy is beneficial in patients with membranous nephropathy.
在一项关于活检证实的特发性膜性肾病治疗效果的回顾性研究中，91名成人和12名儿童在临床发病后随访了长达29年（平均6.5年）。44名患者接受了皮质类固醇治疗，15名患者接受了皮质类固醇和免疫抑制剂治疗；44名患者未接受治疗，作为对照组。治疗组的临床治愈和改善情况显著优于未治疗组（P小于0.01）。未治疗组的复发率、肾衰竭发生率和死亡概率显著更高，尽管其中一些患者最终有所改善。对治疗有反应的患者预后较好。这些数据强烈表明，类固醇治疗对膜性肾病患者有益。
