Bondar O P, Melnykovych G
Kansas City VA Medical Center, USA.
Ukr Biokhim Zh (1978). 1997 Jul-Aug;69(4):17-24.
Inhibitory effects of 1,25(OH)2D3 and D3 on growth of four neoplastically derived cells were observed in human acute leukemia cell culture CEM-C-1 and CEM-C-7, human cervical carcinoma cell lines C-4-1 and human epithelioid carcinoma cells of cervix HeLa S3K. Concurrently, in dexamethasone-responsive cells C-4-1 and HeLa S3K there was a 1,25(OH)2D3 and D3 induced elevation of alkaline phosphatase with 1,25(OH)2D3 showing the greater effects. It is supposed that vitamins D3-induced alkaline phosphatase activity in malignant cells, which is proposed to be a possible marker of cell differentiation, can be associated with the membrane effects of these vitamins.
在人急性白血病细胞培养物CEM-C-1和CEM-C-7、人宫颈癌细胞系C-4-1以及人宫颈上皮样癌细胞HeLa S3K中，观察到1,25(OH)₂D₃和D₃对四种肿瘤衍生细胞生长的抑制作用。同时，在对地塞米松有反应的细胞C-4-1和HeLa S3K中，1,25(OH)₂D₃和D₃诱导碱性磷酸酶升高，其中1,25(OH)₂D₃的作用更强。据推测，维生素D₃诱导恶性细胞中的碱性磷酸酶活性，这被认为可能是细胞分化的一个标志物，可能与这些维生素的膜效应有关。
