D'iakonova V E
Institute of Developmental Biology, Russian Academy of Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Jan-Feb;48(1):113-20.
Keeping specimens of the pond snail Lymnaea stagnalis in the aqueous solution of the opiate antagonist naloxone (0.1 mM) or naltrexone (0.1 mM) resulted in a suppression of motor activity, and, particularly, in a decrease in the rate of ciliary locomotion. The activity of ciliomotor serotonergic neurons of the Pedal A cluster was intracellularly recorded in preparations of isolated ganglia. Naloxone (0.1 mM) suppressed, whereas the opiate agonists morphine (0.1 mM) and DAGO (0.05 mM) accelerated the synaptically driven firing of the Pedal A neurons both in preparations of the entire CNS and isolated pedal ganglia. The obtained results testify to the occurrence of tonic activatory influence of the endogenous opioids on the ciliomotor pedal neurons of snails and suggest that this influence is, at least partially, mediated by their synaptic input.
将池塘蜗牛椎实螺（Lymnaea stagnalis）的样本置于阿片类拮抗剂纳洛酮（0.1 mM）或纳曲酮（0.1 mM）的水溶液中，会导致运动活性受到抑制，尤其是纤毛运动速率降低。在分离神经节的制备物中，对足A簇的纤毛运动5-羟色胺能神经元的活性进行了细胞内记录。在整个中枢神经系统和分离的足神经节的制备物中，纳洛酮（0.1 mM）会抑制，而阿片类激动剂吗啡（0.1 mM）和DAGO（0.05 mM）会加速足A神经元的突触驱动放电。所获得的结果证明内源性阿片类物质对蜗牛的纤毛运动足神经元存在紧张性激活作用，并表明这种作用至少部分是由它们的突触输入介导的。
