Seredenin S B, Kozlovskaia M M, Blednov Iu A, Kozlovskiĭ I I, Semenova T P, Czabak-Garbacz R, Nezavibat'ko V N, Miasoedov N F
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Jan-Feb;48(1):153-60.
The anxiolytic effect of the synthetic analogue of the endogenous peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was studied in inbred mice Balb/c (C) and C57B1/6 (B6) with different heritable types of emotional-stress reaction. In C strain with genetically high level of anxiety and "passive" type of behaviour under conditions of avoidable and unavoidable stress (open field, elevated plus-maze, light-dark chamber) the heptapeptide prevented manifestations of anxiety being administered intraperitoneally in a wide range of active doses (200-3000 mcg/kg). The drug did not change the behaviour of B6 mice with low level of anxiety and active type of emotional-stress reaction. The described effect is comparable with tranquilizing-activatory action of low doses of benzodiazepine tranquillizers, however, in contrast to the latter, the heptapeptide has no side inhibitory behavioural effects even in high doses. The heptapeptide may be considered as a promising new anxioselective drug without side inhibitory behavioural effects which are typical for benzodiazepine tranquillizers.
内源性肽促吞噬素（苏氨酸-赖氨酸-脯氨酸-精氨酸-脯氨酸-甘氨酸-脯氨酸）的合成类似物的抗焦虑作用，在具有不同遗传类型情绪应激反应的近交系小鼠Balb/c（C）和C57B1/6（B6）中进行了研究。在C品系中，在可避免和不可避免的应激条件下（旷场、高架十字迷宫、明暗箱），具有遗传上高水平的焦虑和“被动”行为类型，七肽在广泛的有效剂量（200 - 3000微克/千克）腹腔注射时可预防焦虑表现。该药物对焦虑水平低和具有主动型情绪应激反应的B6小鼠的行为没有影响。所描述的效果与低剂量苯二氮䓬类镇静剂的镇静激活作用相当，然而，与后者不同的是，即使在高剂量下，七肽也没有副作用性的行为抑制作用。七肽可被认为是一种有前景的新型抗焦虑选择性药物，没有苯二氮䓬类镇静剂典型的副作用性行为抑制作用。
