Val'dman A V, Bondarenko N A, Kozlovskaia M M, Rusakov D Iu, Kalikhevich V N
Biull Eksp Biol Med. 1982 Apr;93(4):49-52.
Tuftsin and its Leu1 and D-Arg4 analogs displayed stimulating activity in experimental behavioral despair in mice. In rats with different types of emotional reactions and with destroyed catecholamine terminals (6-OHDA treatment), tuftsin increased exploratory activity, with fear manifestations being decreased and avoidance behavior improved. This was shown while testing the rats in the "open field" and according to the ability to accomplish an extrapolation task of avoiding critical stress-situation. Leu1-tuftsin increased the emotional stress and sharply hindered the avoidance reaction, while D-Arg4-tuftsin modulated the behavior of the animals with increased emotional reactivity and made the avoidance behavior prompter. Pentapeptide, an inhibitor of tuftsin stimulation of phagocytosis, had no significant effect on the behavior. Modifications in the structure of tuftsin resulted both in the changes in phagocytosis-stimulating activity and the appearance of other psychotropic effects.
吞噬细胞增强素及其亮氨酸1和D-精氨酸4类似物在小鼠实验性行为绝望中表现出刺激活性。在具有不同类型情绪反应且儿茶酚胺终末被破坏（6-羟基多巴胺处理）的大鼠中，吞噬细胞增强素增加了探索活动，恐惧表现减少，回避行为得到改善。这是在“旷场”试验中对大鼠进行测试时，并根据其完成避免临界应激情况的外推任务的能力显示出来的。亮氨酸1-吞噬细胞增强素增加了情绪应激并严重阻碍了回避反应，而D-精氨酸4-吞噬细胞增强素调节了情绪反应性增加的动物的行为，并使回避行为更加迅速。五肽是吞噬细胞增强素刺激吞噬作用的抑制剂，对行为没有显著影响。吞噬细胞增强素结构的改变既导致了吞噬作用刺激活性的变化，也导致了其他精神otropic效应的出现。
