Fuse S, Tomita H, Chiba S
Department of Pediatrics, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Jpn Circ J. 1998 Mar;62(3):193-7. doi: 10.1253/jcj.62.193.
Plasma thromboxane B2 (TXB2)-a stable metabolite of thromboxane A2 (TXA2)-conventional hemodynamic parameters, mean pulmonary input energy (input energy), and mean pulmonary output energy (output energy) were measured to assess platelet activation in 21 patients with pulmonary hypertension and a ventricular septal defect (VSD). The patients were divided into 2 groups: group A (normal range) and group B (high level). TXB2 levels were measured by radioimmunoassay. There was no relationship between plasma TXB2 concentrations and conventional hemodynamic parameters except the pulmonary-to-systemic pressure ratio. Output-to-input energy ratio was correlated logarithmically with the plasma TXB2 concentration. We concluded that patients with output/input energy ratio >0.15 had a high TXB2 concentration and activated platelets in pulmonary capillaries.
检测了21例患有肺动脉高压和室间隔缺损（VSD）患者的血浆血栓素B2（TXB2）——血栓素A2（TXA2）的稳定代谢产物——以及传统血流动力学参数、平均肺输入能量（输入能量）和平均肺输出能量（输出能量），以评估血小板活化情况。患者被分为2组：A组（正常范围）和B组（高水平）。通过放射免疫测定法检测TXB2水平。除了肺循环与体循环压力比值外，血浆TXB2浓度与传统血流动力学参数之间无相关性。输出能量与输入能量比值与血浆TXB2浓度呈对数相关。我们得出结论，输出/输入能量比值>0.15的患者TXB2浓度较高，且肺毛细血管中的血小板处于活化状态。
