Murakami S, Nakashiro Y, Mizobuchi M, Hato N, Honda N, Gyo K
Department of Otolaryngology, Ehime University School of Medicine, Japan.
Acta Otolaryngol. 1998 Mar;118(2):145-9. doi: 10.1080/00016489850154829.
The pathogenesis of facial nerve paralysis and vestibulo-cochlear dysfunction of Ramsay Hunt syndrome remains unclear as varicella-zoster virus (VZV) has not been demonstrated in the lesions. Using the polymerase chain reaction, we detected VZV genomes not only in the vesicles on the auricles or oral cavity but also in the facial nerve sheath, middle ear mucosa and cerebrospinal fluid from patients with Ramsay Hunt syndrome. The VZV genome was undetectable in the same kinds of clinical samples obtained from control patients with facial nerve paralysis of other etiologies. The results indicated that VZV spreads widely in the neural components, mucocutaneous tissue and cerebrospinal fluid. The present study will facilitate better understanding of the pathogenesis of facial nerve paralysis, vertigo, hearing impairment and other cranial nerve dysfunction of Ramsay Hunt syndrome.
由于在病变中尚未发现水痘-带状疱疹病毒（VZV），拉姆齐·亨特综合征的面神经麻痹和前庭蜗功能障碍的发病机制仍不清楚。我们使用聚合酶链反应，不仅在耳廓或口腔的水疱中，还在拉姆齐·亨特综合征患者的面神经鞘、中耳黏膜和脑脊液中检测到了VZV基因组。在从其他病因的面神经麻痹对照患者获得的相同类型临床样本中未检测到VZV基因组。结果表明，VZV在神经成分、黏膜皮肤组织和脑脊液中广泛传播。本研究将有助于更好地理解拉姆齐·亨特综合征的面神经麻痹、眩晕、听力障碍和其他颅神经功能障碍的发病机制。
