A naturalistic study of home detoxification from opiates using lofexidine.

The study describes the outcome of home detoxification from opiates using lofexidine, a centrally-acting alpha2-adrenergic agonist, in a consecutive series of 28 unselected individuals. Eleven detoxifications (39%) were successful and 17 (61%) unsuccessful. No major medical or psychological problems were reported. Successful outcome was associated with not using heroin, good compliance with a methadone programme and prediction of success by the key worker. Home detoxification using lofexidine appears to be a useful treatment for some opiate-dependent individuals, and is most likely to be successful in those individuals whose drug use is already well-controlled.