Feet B A, Medbö S, Rootwelt T, Ganes T, Saugstad O D
Department of Pediatric Research, Institute for Surgical Research, National Hospital, Oslo, Norway.
Pediatr Res. 1998 May;43(5):690-6. doi: 10.1203/00006450-199805000-00019.
We tested the hypothesis that hypoxic newborn piglets can be successfully resuscitated with lower O2 concentrations than 21%. Severely hypoxic, 2-4-d-old, anesthetized piglets were randomly divided into five resuscitation groups: 21% O2 (n = 10), 18% O2 (n = 9), 15% O2 (n = 9), 12% O2 (n = 8), all normoventilated, and a hypoventilated 21% O2 group (PaCO2; 7.0-8.0 kPa, n = 9). Base excess (BE) reached -20 +/- 1 mmol/L at the end of hypoxia. After 3 h of resuscitation, BE had risen to -4 +/- 1 mmol/L in the 21% O2, 18% O2, and hypoventilated groups, but was -10 +/- 2 mmol/L in the 15% O2 group (p < 0.05 versus 21% O2 group) and -22 +/- 2 mmol/L in the 12% O2 group (p < 0.05 versus 21% O2 group). Four animals died during resuscitation, all allocated to the 12% O2 group (p < 0.05 versus 21% O2 group). Somatosensory evoked potentials (SEPs) recovered in 39 of 45 piglets, and remained present during resuscitation in all except the 12% O2 group. SEP recovered initially even in six of eight animals in the 12% O2 group, but disappeared again in all later during resuscitation. The SEP amplitude recovered to levels not significantly different from the 21% O2 group in all groups except the 12% O2 group. Plasma hypoxanthine concentrations and extracellular hypoxanthine concentrations in the striatum decreased during resuscitation to levels not significantly different from the 21% O2 group in all but the 12% O2 group (p < 0.05 versus 21% O2 group). In conclusion, severely hypoxic newborn piglets were resuscitated as efficiently with both hypoventilation and 18% O2 as with 21% O2.
与使用21%的氧气浓度相比，低氧浓度能够成功复苏新生缺氧仔猪。将2至4日龄、处于严重缺氧状态且已麻醉的仔猪随机分为五个复苏组：21%氧气组（n = 10）、18%氧气组（n = 9）、15%氧气组（n = 9）、12%氧气组（n = 8），所有组均进行正常通气，以及一个通气不足的21%氧气组（动脉血二氧化碳分压；7.0 - 8.0 kPa，n = 9）。缺氧结束时，碱剩余（BE）达到 -20 ± 1 mmol/L。复苏3小时后，21%氧气组、18%氧气组和通气不足组的BE升至 -4 ± 1 mmol/L，但15%氧气组为 -10 ± 2 mmol/L（与21%氧气组相比，p < 0.05），12%氧气组为 -22 ± 2 mmol/L（与21%氧气组相比，p < 0.05）。复苏过程中有4只动物死亡，均分配至12%氧气组（与21%氧气组相比，p < 0.05）。45只仔猪中有39只的体感诱发电位（SEP）恢复，除12%氧气组外，其他组在复苏过程中SEP一直存在。即使在12%氧气组的8只动物中有6只最初SEP恢复，但在复苏后期所有动物的SEP又消失了。除12%氧气组外，所有组的SEP振幅恢复到与21%氧气组无显著差异的水平。除12%氧气组外，所有组在复苏过程中血浆次黄嘌呤浓度和纹状体细胞外次黄嘌呤浓度降至与21%氧气组无显著差异的水平（与21%氧气组相比，p < 0.05）。总之，严重缺氧的新生仔猪采用通气不足和18%氧气进行复苏的效果与采用21%氧气一样有效。
