Feet B A, Gilland E, Groenendaal F, Brun N C, Hellström-Westas L, Hagberg H, Saugstad O D
Department of Paediatric Research and Institute for Surgical Research, National Hospital, Oslo, Norway.
Acta Paediatr. 1998 Aug;87(8):889-95. doi: 10.1080/080352598750013699.
We tested the hypothesis that early brain recovery in hypoxic newborn piglets is improved by resuscitating with an O2 supply close to the minimum level required by the newborn piglet brain. Severely hypoxic 2-5-d-old anaesthetized piglets were randomly divided into three resuscitation groups: hypoxaemic (n = 8), 21% O2 (n = 8), and 100% O2 groups (n = 8). The hypoxaemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%, mean +/- SEM). During the 2h resuscitation period, extracellular aspartate and glutamate concentrations in the cerebral striatum were higher during hypoxaemic resuscitation (p = 0.044 and p = 0.055, respectively) than during resuscitation with 21% O2 or 100% O2, suggesting an unfavourable accumulation of potent excitotoxins during hypoxaemic resuscitation. The cell membrane Na+,K+-ATPase activity of cerebral cortical tissue after 2 h resuscitation was similar in the three groups (p = 0.30). In conclusion, hypoxaemic resuscitation did not normalize early cerebral metabolic recovery as efficiently as resuscitation with 21% O2 or 100% O2. Resuscitation with 21% O2 was as efficient as resuscitation with 100% O2 in this newborn piglet hypoxia model.
用接近新生仔猪大脑所需最低水平的氧气供应进行复苏，可改善缺氧新生仔猪的早期脑恢复情况。将2至5日龄严重缺氧的麻醉仔猪随机分为三组进行复苏：低氧血症组（n = 8）、21%氧气组（n = 8）和100%氧气组（n = 8）。低氧血症组通过机械通气给予12 - 18%的氧气，调整通气量以使脑静脉血氧饱和度达到17 - 23%（基线水平；45±1%，平均值±标准误）。在2小时的复苏期间，与用21%氧气或100%氧气复苏相比，低氧血症复苏期间纹状体细胞外天冬氨酸和谷氨酸浓度更高（分别为p = 0.044和p = 0.055），这表明低氧血症复苏期间有强效兴奋性毒素的不利蓄积。复苏2小时后，三组大脑皮质组织的细胞膜钠钾ATP酶活性相似（p = 0.30）。总之，与用21%氧气或100%氧气复苏相比，低氧血症复苏并不能同样有效地使早期脑代谢恢复正常。在这个新生仔猪缺氧模型中，用21%氧气复苏与用100%氧气复苏的效果一样。
