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大鼠血浆和肠激肽释放酶的分子量

The molecular weights of plasma and intestinal kallikreins in rats.

作者信息

Zeitlin I J, Singh Y N, Lembeck F, Theiler M

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1976 May;293(2):159-61. doi: 10.1007/BF00499221.

DOI:10.1007/BF00499221
PMID:958504
Abstract
  1. The molecular weights of kallikreins of rat intestine and rat plasma have been estimated using gel filtration. 2. Extracts of pooled tissue from rat jejunum, ileum, caecum and colon activated by autolytic processes gave a single peak of kallikrein activity with a molecular weights of 33000. 3. Acid-activated rat plasma gave two peaks of kallikrein activity with molecular weight of 125000 and 61500. 4. Rat intestinal tissue contains a kinin forming enzyme having a molecular weight similar to those of glandular kallikreins and different from those of the rat plasma kallikreins.
摘要
  1. 已使用凝胶过滤法估算了大鼠肠道和大鼠血浆激肽释放酶的分子量。2. 来自大鼠空肠、回肠、盲肠和结肠的合并组织提取物经自溶过程激活后,激肽释放酶活性呈现单峰,分子量为33000。3. 酸激活的大鼠血浆产生了两个激肽释放酶活性峰,分子量分别为125000和61500。4. 大鼠肠道组织含有一种激肽形成酶,其分子量与腺激肽释放酶相似,与大鼠血浆激肽释放酶不同。

相似文献

1
The molecular weights of plasma and intestinal kallikreins in rats.大鼠血浆和肠激肽释放酶的分子量
Naunyn Schmiedebergs Arch Pharmacol. 1976 May;293(2):159-61. doi: 10.1007/BF00499221.
2
The effect of diet on tissue levels of kinin-forming enzyme in blood-free rat gastro-intestinal tract.饮食对无血大鼠胃肠道中激肽形成酶组织水平的影响。
J Physiol. 1980 Jan;298:361-70. doi: 10.1113/jphysiol.1980.sp013086.
3
Existence of prokallikrein in the kidney. Its biochemical properties compared to three active glandular kallikreins from the kidney, serum, and urine of the rat.肾脏中激肽释放酶原的存在。将其生化特性与来自大鼠肾脏、血清和尿液的三种活性腺体激肽释放酶进行比较。
Hypertension. 1983 Mar-Apr;5(2):205-10. doi: 10.1161/01.hyp.5.2.205.
4
Isolation and characterization of rat plasma glandular kallikrein.大鼠血浆腺激肽释放酶的分离与特性鉴定
Biochem Pharmacol. 1985 Jan 1;34(1):51-6. doi: 10.1016/0006-2952(85)90099-1.
5
Hydrolysis of rat high molecular weight kininogen by purified rat urinary kallikrein: identification of bradykinin as the kinin formed.纯化的大鼠尿激肽释放酶对大鼠高分子量激肽原的水解作用:鉴定缓激肽为所形成的激肽。
Adv Exp Med Biol. 1986;198 Pt A:137-45. doi: 10.1007/978-1-4684-5143-6_19.
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Kallikrein-kinin and renin-angiotensin systems in rat renal lymph.大鼠肾淋巴中的激肽释放酶-激肽系统和肾素-血管紧张素系统
Kidney Int. 1984 Jun;25(6):880-5. doi: 10.1038/ki.1984.105.
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Rat stomach kallikrein: its purification and properties.大鼠胃激肽释放酶:其纯化及性质
Adv Exp Med Biol. 1979;120A:291-303. doi: 10.1007/978-1-4757-0926-1_28.
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Characterization and origin of immunoreactive glandular kallikrein in rat plasma.
Biochem Pharmacol. 1981 Jul 1;30(13):1731-7. doi: 10.1016/0006-2952(81)90002-2.
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Purification and properties of rat stomach kallikrein.大鼠胃激肽释放酶的纯化及性质
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Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem).落叶型天疱疮(巴西落叶型天疱疮)患者血浆和组织激肽释放酶、血浆激肽酶II及唾液激肽释放酶活性增加。
Br J Dermatol. 2005 Apr;152(4):650-7. doi: 10.1111/j.1365-2133.2005.06427.x.

引用本文的文献

1
Kinins stimulate net chloride secretion by the rat colon.激肽刺激大鼠结肠的净氯化物分泌。
Br J Pharmacol. 1982 Apr;75(4):587-98. doi: 10.1111/j.1476-5381.1982.tb09178.x.
2
Changes in colonic tissue levels of inflammatory mediators in a guinea-pig model of immune colitis.免疫性结肠炎豚鼠模型中结肠组织炎症介质水平的变化
Agents Actions. 1982 Apr;12(1-2):243-6. doi: 10.1007/BF01965154.
3
The effect of diet on tissue levels of kinin-forming enzyme in blood-free rat gastro-intestinal tract.饮食对无血大鼠胃肠道中激肽形成酶组织水平的影响。

本文引用的文献

1
Observations on intrinsic kinin-forming factors in human plasma: the effect of acid, acetone, chloroform, heat and euglobulin separation on kinin formation.人血浆中内源性激肽形成因子的观察:酸、丙酮、氯仿、热和优球蛋白分离对激肽形成的影响。
J Physiol. 1963 May;166(3):496-513. doi: 10.1113/jphysiol.1963.sp007119.
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A STABLE SUBSTRATE FOR THE ASSAY OF PLASMA KININ-FORMING ENZYMES.用于测定血浆激肽形成酶的稳定底物。
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The fibrin plate method for estimating fibrinolytic activity.
J Physiol. 1980 Jan;298:361-70. doi: 10.1113/jphysiol.1980.sp013086.
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Mobilization of colonic kallikrein following pelvic nerve stimulation in the atropinized cat.阿托品化猫盆腔神经刺激后结肠激肽释放酶的动员
J Physiol. 1978 Dec;285:471-8. doi: 10.1113/jphysiol.1978.sp012583.
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An unpublished work of Stephen Hales (1677-1761) [proceedings].斯蒂芬·黑尔斯(1677 - 1761)的一篇未发表作品[会议记录] 。
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用于评估纤维蛋白溶解活性的纤维蛋白平板法。
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Determination of plasmakinin & kininogen levels in man.人体血浆激肽和激肽原水平的测定。
J Physiol. 1967 Jul;191(2):417-26. doi: 10.1113/jphysiol.1967.sp008259.
5
The gel-filtration behaviour of proteins related to their molecular weights over a wide range.蛋白质的凝胶过滤行为与其在很宽范围内的分子量相关。
Biochem J. 1965 Sep;96(3):595-606. doi: 10.1042/bj0960595.
6
Kinin-forming and destroying activities of cell homogenates.细胞匀浆的激肽形成和破坏活性。
J Physiol. 1965 Aug;179(3):479-88. doi: 10.1113/jphysiol.1965.sp007674.
7
Pharmacological characterization of kinin-forming activity in rat intestinal tissue.大鼠肠道组织中激肽形成活性的药理学特性
Br J Pharmacol. 1971 Aug;42(4):648P-649P.
8
Studies on the prekallikrein (kallikreinogen)--kallikrein enzyme system of human plasma. I. Isolation and purification of plasma kallikreins.人血浆前激肽释放酶(激肽原)-激肽释放酶酶系统的研究。I. 血浆激肽释放酶的分离与纯化。
J Clin Invest. 1969 Jan;48(1):11-22. doi: 10.1172/JCI105959.
9
Mobilization of tissue kallikrein in inflammatory disease of the colon.结肠炎性疾病中组织激肽释放酶的动员
Gut. 1973 Feb;14(2):133-8. doi: 10.1136/gut.14.2.133.
10
Estimation of the molecular weights of proteins by Sephadex gel-filtration.用葡聚糖凝胶过滤法估算蛋白质的分子量
Biochem J. 1964 May;91(2):222-33. doi: 10.1042/bj0910222.