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急性百草枯中毒:一例高酒精摄入量患者毒性增加

Acute paraquat poisoning: increased toxicity in one case with high alcohol intake.

作者信息

Ernouf D, Boussa N, Legras A, Dutertre-Catella H

机构信息

Laboratoire de Toxicologie, Faculté de Pharmacie, Tours, France.

出版信息

Hum Exp Toxicol. 1998 Mar;17(3):182-4. doi: 10.1177/096032719801700310.

DOI:10.1177/096032719801700310
PMID:9587788
Abstract

Human paraquat poisoning from accidental or intentional ingestion is very often fatal. According to the amount of paraquat involved, death can occur within hours or weeks following ingestion. The inefficacy of the various treatments undertaken have led to determine prognostic factors based upon the evolution of plasma and urine paraquat concentrations or of usual biochemical parameters. We report one case of acute poisoning which, although the ingested dose of paraquat was not massive (< 50 mg/kg-1) and the severity indices were in favour of a delayed fatal outcome, has ended in an early death. The high blood alcohol level of the patient (3.34 g l-1) seems to be the main cause of the precocity of this death (86th hour).

摘要

人类因意外或故意摄入百草枯而中毒往往是致命的。根据摄入百草枯的量,摄入后数小时或数周内可能会死亡。所采取的各种治疗方法均无效,因此已根据血浆和尿液中百草枯浓度的变化或常规生化参数来确定预后因素。我们报告一例急性中毒病例,尽管摄入的百草枯剂量不大(<50 mg/kg-1)且严重程度指标表明会出现延迟性致命结局,但患者却早亡。患者血液中酒精含量高(3.34 g l-1)似乎是导致此次早亡(第86小时)的主要原因。

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