Holécyová A, Kriska M
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovakia.
Bratisl Lek Listy. 1998 Feb;99(2):99-103.
Experiments were designed to determine whether ambroxol, a drug used for the treatment of respiratory disorders, affects the basal tension and/or contractions due to adrenergic stimuli in the isolated rabbit portal vein and pulmonary artery. Ambroxol in concentrations of 10(-6)-10(-4) mol/l produced a concentration-dependent increase in basal tension, but a decrease in spontaneous mechanical activity of portal vein. The same concentrations of ambroxol failed to influence basal tension of pulmonary artery. However, when the vessel tone was increased by exogenous noradrenaline, ambroxol elicited concentration-dependent contractions also in this vessel. Moreover, ambroxol in the concentration of 10(-5) mol/l significantly enhanced vascular contractions due to both exo- and endogenous noradrenaline. The results suggest that ambroxol, in biologically relevant concentrations, may influence or even induce vascular contractions to adrenergic stimuli. Their expression, however, depend on the type of vascular smooth muscle. (Fig. 7, Ref. 25.)
设计实验以确定氨溴索（一种用于治疗呼吸系统疾病的药物）是否影响离体兔门静脉和肺动脉因肾上腺素能刺激引起的基础张力和/或收缩。浓度为10（-6）-10（-4）mol/L的氨溴索可使基础张力呈浓度依赖性增加，但会降低门静脉的自发机械活性。相同浓度的氨溴索未能影响肺动脉的基础张力。然而，当通过外源性去甲肾上腺素增加血管张力时，氨溴索在该血管中也会引起浓度依赖性收缩。此外，浓度为10（-5）mol/L的氨溴索可显著增强外源性和内源性去甲肾上腺素引起的血管收缩。结果表明，在生物学相关浓度下，氨溴索可能影响甚至诱导血管对肾上腺素能刺激的收缩。然而，其表现取决于血管平滑肌的类型。（图7，参考文献25）
