el-Charkawi H, el-Said E A, Safouh H M, el-Raghi N
Prosthodontics Dep., Faculty of Oral and Dental Medicine, Cairo University.
Egypt Dent J. 1994 Jul;40(3):785-90.
This study aimed at evaluating the incorporation of two antimicrobial drugs (nystatin and polynoxylin) as regards: the effect of the liner on the activity of the drug, determination of the least effective concentration of each drug and its duration of action, as well as assessment of the effect of the drug on the mechanical properties and the chemical composition of the liner. Results showed that nystatin added to denture liners in three different concentrations by weight (3%, 5%, 10%) acted effectively against Candida albicans, and that there was a direct relationship between concentration of Nystatin and its duration of action. The inhibitory effect of nystatin (10%) lasted for at least 32 weeks (end of study period). Furthermore, this concentration did not affect the strength properties of the liner. On the other hand, polynoxylin inhibited a number of strains of bacteria and Candida only in high concentrations (40-60%), and these concentrations adversely affected the strength properties of the liner.
本研究旨在评估两种抗菌药物（制霉菌素和多聚甲醛）的掺入情况，具体涉及：衬垫对药物活性的影响、每种药物最低有效浓度及其作用持续时间的测定，以及药物对衬垫机械性能和化学成分的影响。结果表明，以三种不同重量浓度（3%、5%、10%）添加到义齿衬垫中的制霉菌素对白色念珠菌有有效作用，且制霉菌素浓度与其作用持续时间之间存在直接关系。制霉菌素（10%）的抑制作用持续至少32周（研究期末）。此外，该浓度不影响衬垫的强度性能。另一方面，多聚甲醛仅在高浓度（40 - 60%）时抑制多种细菌和念珠菌菌株，且这些浓度对衬垫的强度性能有不利影响。
