Spiechowicz E, Santarpia R P, Pollock J J, Renner R P
Quintessence Int. 1990 Jan;21(1):35-40.
This study evaluated at the in vitro level the antifungal effectiveness of nystatin, chlorhexidine, and a homologous histidine polypeptide on the surface of acrylic resin disks. The agents were used in a way that simulated storage of a denture by a denture wearer. Results indicated that pretreatment with poly-L-histidine was not protective against C albicans adherence and growth regardless of whether disks were stored in water or in the open air for the 8-hour period following yeast contamination. Chlorhexidine was totally effective in preventing C albicans attachment to, and growth on, the acrylic resin, even after a period of 8 days of turbidimetric monitoring. Pretreatment with Nystatin, followed by drying, was protective, yielding results similar to those obtained with chlorhexidine.
本研究在体外水平评估了制霉菌素、氯己定和一种同源组氨酸多肽对丙烯酸树脂盘表面的抗真菌效果。这些药剂的使用方式模拟了义齿佩戴者对义齿的储存情况。结果表明，无论圆盘在酵母污染后的8小时内是储存在水中还是暴露在空气中，用聚-L-组氨酸预处理都不能防止白色念珠菌的附着和生长。即使经过8天的比浊法监测，氯己定在防止白色念珠菌附着于丙烯酸树脂并在其上生长方面完全有效。用制霉菌素预处理后干燥具有保护作用，其结果与氯己定相似。
