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上橄榄复合体的海人酸损伤:对白化大鼠声音定位的影响。

Kainic acid lesions of the superior olivary complex: effects on sound localization by the albino rat.

作者信息

van Adel B A, Kelly J B

机构信息

Psychology Department, Carleton University, Ottawa, Ontario, Canada.

出版信息

Behav Neurosci. 1998 Apr;112(2):432-46. doi: 10.1037//0735-7044.112.2.432.

DOI:10.1037//0735-7044.112.2.432
PMID:9588489
Abstract

The ability of rats to localize sounds in space was determined before and after kainic acid lesions of the superior olivary complex (SOC). Animals were tested with a 45-ms noise burst delivered from loudspeakers on the right or left of midline. Anatomical data showed that the lesions destroyed neurons in SOC while preserving fibers of passage in the trapezoid body and other decussating pathways of the auditory brainstem. Animals with either unilateral or bilateral SOC lesions were impaired in their ability to localize a single noise burst postoperatively. Deficits were also found after unilateral lesions restricted primarily to the lateral superior olive. SOC lesions resulted in an elevation in minimum audible angles for sound localization.

摘要

在对大鼠上橄榄复合体(SOC)进行 kainic 酸损伤前后,测定了大鼠在空间中定位声音的能力。用从位于中线右侧或左侧的扬声器发出的 45 毫秒噪声脉冲对动物进行测试。解剖学数据表明,损伤破坏了 SOC 中的神经元,同时保留了梯形体内的传导纤维以及听觉脑干的其他交叉通路。单侧或双侧 SOC 损伤的动物在术后定位单个噪声脉冲的能力上受损。主要局限于外侧上橄榄核的单侧损伤后也发现了缺陷。SOC 损伤导致声音定位的最小可听角度升高。

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