毒性多结节性甲状腺肿患者的治疗。

Treatment of patients with toxic multinodular goiter.

作者信息

Erickson D, Gharib H, Li H, van Heerden J A

机构信息

Division of Endocrinology, Metabolism, Nutrition and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

出版信息

Thyroid. 1998 Apr;8(4):277-82. doi: 10.1089/thy.1998.8.277.

DOI:10.1089/thy.1998.8.277

PMID:9588491

Abstract

The medical records of 253 patients evaluated for toxic multinodular goiter from 1975 through 1993 were reviewed to determine treatment trends, success, and complications. Of the 235 (93%) treated, 174 (74%) received surgical treatment and 61 (26%) received radioiodine (131I) treatment. Three months after initial treatment, 82% of surgically treated patients became euthyroid or hypothyroid compared with 21% of the 131I group. Among the 131I-treated patients, 20% required a second treatment, whereas none needed further treatment in the surgical group. At 2 years, the estimated probability of success was similar. The probability of post-treatment hypothyroidism was significantly higher for surgically treated patients, which is expected.

摘要

回顾了1975年至1993年间对253例毒性多结节性甲状腺肿患者的评估病历，以确定治疗趋势、成功率和并发症情况。在235例（93%）接受治疗的患者中，174例（74%）接受了手术治疗，61例（26%）接受了放射性碘（131I）治疗。初始治疗三个月后，82%接受手术治疗的患者甲状腺功能恢复正常或出现甲状腺功能减退，而131I治疗组这一比例为21%。在接受131I治疗的患者中，20%需要进行第二次治疗，而手术组中无人需要进一步治疗。两年时，估计成功率相似。手术治疗患者治疗后发生甲状腺功能减退的概率明显更高，这是意料之中的。