Mano T, Sakamoto H, Fujita K, Makino M, Kakizawa H, Nagata M, Kotake M, Hamada M, Uchimura K, Hayakawa N, Hayashi R, Nakai A, Itoh M, Kuzuya H, Nagasaka A
Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Thyroid. 1998 Apr;8(4):353-8. doi: 10.1089/thy.1998.8.353.
Clinical and experimental data suggest that thyroid hormone affects the actions of catecholamine (CA). However, the serum or tissue levels of CA during thyroid disorders have not been well defined. Accordingly, we investigated the levels of CA and their metabolites in the cardiac muscle, the cerebral cortex, and the plasma of rats with hyperthyroidism and hypothyroidism versus euthyroid animals. The Neurochem analyzer system (ESA, Inc., Bedford, MA) was used in such determinations. The cardiac muscles of hyperthyroid rats exhibited a 16% decrease in the levels of 1-dopa, 3-methoxytyramine (3-MT) and homovanillic acid (HVA) as compared with those in euthyroid rats. The levels of norepinephrine (NE) in cardiac muscle of these rats increased significantly (5.2-fold) relative to the levels in euthyroid rats. NE was undetectable in the cardiac muscles of the hypothyroid rats. Epinephrine (E) and dopamine (DA) were not detected in the cardiac muscles of the rats with either thyroid disorder. Levels of E and 3,4-dihydroxymandelic acid (DOPEG) were detected only in the cerebral cortex of hyperthyroid rats. The cerebral cortex levels of 3-methyoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), metanephrine (MN), and homovanillic acid (HVA) were all significantly increased in the hyperthyroid versus the euthyroid rats. The cerebral cortex levels of DA, NE, normetanephrine (NMN), and VMA in the hyperthyroid rats all showed a significant decrease. Levels of NE, NMN, and DOPAC in the cerebral cortex increased significantly in the hypothyroid rats. The level of VMA was undetectable in cerebral cortex of such animals. Data from studies on cardiac muscle and cerebral cortex indicate that the changes in CA and CA metabolites are responsible in part for the cardiovascular and the central nervous system symptoms observed in hyperthyroidism and hypothyroidism.
临床和实验数据表明，甲状腺激素会影响儿茶酚胺（CA）的作用。然而，甲状腺疾病期间CA的血清或组织水平尚未明确界定。因此，我们研究了甲状腺功能亢进和甲状腺功能减退大鼠与甲状腺功能正常动物相比，其心肌、大脑皮层和血浆中CA及其代谢物的水平。此类测定使用了神经化学分析仪系统（ESA公司，马萨诸塞州贝德福德）。与甲状腺功能正常的大鼠相比，甲状腺功能亢进大鼠的心肌中，1-多巴、3-甲氧基酪胺（3-MT）和高香草酸（HVA）水平降低了16%。这些大鼠心肌中的去甲肾上腺素（NE）水平相对于甲状腺功能正常的大鼠显著升高（5.2倍）。在甲状腺功能减退大鼠的心肌中未检测到NE。无论是哪种甲状腺疾病的大鼠，其心肌中均未检测到肾上腺素（E）和多巴胺（DA）。仅在甲状腺功能亢进大鼠的大脑皮层中检测到E和3,4-二羟基扁桃酸（DOPEG）的水平。与甲状腺功能正常的大鼠相比，甲状腺功能亢进大鼠大脑皮层中的3-甲氧基酪胺（3-MT）、3,4-二羟基苯乙酸（DOPAC）、间甲肾上腺素（MN）和高香草酸（HVA）水平均显著升高。甲状腺功能亢进大鼠大脑皮层中的DA、NE、去甲变肾上腺素（NMN）和香草扁桃酸（VMA）水平均显著降低。甲状腺功能减退大鼠大脑皮层中的NE、NMN和DOPAC水平显著升高。在此类动物的大脑皮层中未检测到VMA水平。心肌和大脑皮层的研究数据表明，CA及其代谢物的变化部分导致了甲状腺功能亢进和甲状腺功能减退时观察到的心血管和中枢神经系统症状。
