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二甲基苯并蒽植入雄性白化大鼠舌深层黏膜下层诱导间叶性肿瘤

Induction of mesenchymal neoplasms by DMBA implantation in deep lingual submucosa of male albino rats.

作者信息

Fathy L M

机构信息

Faculty of Oral and Dental Medicine, Cairo University.

出版信息

Egypt Dent J. 1993 Jul;39(3):491-4.

PMID:9590976
Abstract

45 male albino rats were used to study the effect of deep submucosal implantation of DMBA on lingual carcinogenesis. The results showed development of different mesenchymal neoplasms (fibroma, fibrosarcoma and leiomyosarcoma). So, this method of implantation could not be used as an ideal animal model for production of single known neoplasm as had been investigated by many investigators before.

摘要

45只雄性白化病大鼠被用于研究二甲基苯并蒽（DMBA）黏膜下深层植入对舌癌发生的影响。结果显示出现了不同的间叶性肿瘤（纤维瘤、纤维肉瘤和平滑肌肉瘤）。因此，正如之前许多研究者所研究的那样，这种植入方法不能用作产生单一已知肿瘤的理想动物模型。

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